Aging-Driven Fibro-Adipogenic Progenitor Dysregulation in Inguinal Hernia

An integrative single-cell and genetic multi-omics study to identify causal aging-related FAP mechanisms underlying inguinal hernia susceptibility.

Status: Ongoing  ·  Category: Research / Multi-Omics / Single-Cell Genomics / Causal Inference  ·  Includes: snRNA-seq & snATAC-seq integration, FAP subpopulation analysis, SMR/HEIDI, hdWGCNA, fine-mapping (COJO, SuSiE), transcription factor and regulatory network analysis.


1. Statement of the Problem and Rationale


2. Research Objectives


3. Methodological Framework

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3.1 Data Sources

3.2 Genetic Instrument Selection and Validation

3.3 Statistical Analysis Plan


4. Expected Outcomes and Scientific Significance


References