CV

A PDF version of the CV is available for download above.

Personal Information

Full Name Hani Sabaie
Emails sabaie.hani@gmail.com • sabaieh@tbzmed.ac.ir
Website https://hani-sabaie.github.io
Google Scholar Google Scholar
ORCID ORCID
GitHub GitHub
LinkedIn LinkedIn
ResearchGate ResearchGate
Web of Science Web of Science

Education

  • 2018 - 2021
    Master of Science in Human Genetics
    Tabriz University of Medical Sciences | Tabriz, Iran
    • GPA: 4/4
    • Tuition-Free Master's Degree Program
    • Thesis: Analysis of BCAS4/hsa-miR-185-5p/SHISA7 Competing Endogenous RNA Axis in Late-onset Alzheimer’s Disease.
    • Supervisor: Dr. Maryam Rezazadeh
  • 2012 – 2017
    Bachelor of Science in Biology - Animal Sciences
    University of Guilan | Rasht, Iran
    • GPA: 3.37/4
    • Tuition-Free Bachelor's Degree Program
    • Project: Genome Evolution
    • Mentor: Dr. Shohreh Siyam

Research Interests

  • Statistical and Computational Genomics
  • Structural Variation and Variant-to-Function Mapping
  • Functional Genomics and Gene Regulation
  • Clinical Transcriptomics and RNA Sequencing
  • Single-Cell Multiomics Analysis

Peer-Reviewed Publications

  • 1. Saed A, Akbarzadeh M, Gohari F, Asadrouh N, Jahromizadeh AM, Sabaie H, Zarkesh M, Hedayati M, Azizi F, Daneshpour MS. Serum ferritin and delirium risk: an integrative genomic analysis of causal inference and multi-tissue regulatory signals. Human Genomics. 2026. https://doi.org/10.1186/s40246-026-00972-5
  • 2. Sabaie H, Taghavi Rad A, Shabestari M, Habibi D, Saadattalab T, Seddiq S, Saeidian AH, Zahedi AS, Sanoie M, Vahidnezhad H, Zarkesh M, Foroutani L, Hakonarson H, Azizi F, Hedayati M, Daneshpour MS, Akbarzadeh M. Mitochondrial DNA Copy Number as a Hidden Player in the Progression of Multiple Sclerosis: A Bidirectional Two-Sample Mendelian Randomization Study. Molecular Neurobiology. 2025;62(9):11643-53. https://doi.org/10.1007/s12035-025-04980-9
  • 3. Sabaie H, Taghavi Rad A, Shabestari M, Seddiq S, Saadattalab T, Habibi D, Saeidian AH, Abbasi M, Mirtavoos-Mahyari H. Deciphering the bidirectional impact of leukocyte telomere length on multiple sclerosis progression: A Mendelian randomization study. Multiple Sclerosis and Related Disorders. 2025;94:106277. https://doi.org/10.1016/j.msard.2025.106277
  • 4. Shoaran M, Sabaie H, Mostafavi M, Rezazadeh M. A comprehensive review of the applications of RNA sequencing in celiac disease research. Gene. 2024;927:148681. https://doi.org/10.1016/j.gene.2024.148681
  • 5. Asadi MR, Gharesouran J, Sabaie H, Zaboli Mahdiabadi M, Mazhari SA, Sharifi-Bonab M, Shirvani-Farsani Z, Taheri M, Sayad A, Rezazadeh M. Neurotrophin growth factors and their receptors as promising blood biomarkers for Alzheimer’s Disease: a gene expression analysis study. Molecular Biology Reports. 2024;51(1). http://dx.doi.org/10.1007/s11033-023-08959-4
  • 6. Sabaie H, Tamimi P, Gharesouran J, Salkhordeh Z, Asadi MR, Sharifi-Bonab M, Shirvani-Farsani Z, Taheri M, Sayad A, Rezazadeh M. Expression analysis of inhibitory B7 family members in Alzheimer’s disease. Metabolic Brain Disease. 2023;38(8):2563-72. http://dx.doi.org/10.1007/s11011-023-01274-8
  • 7. Moghadam YJ, Asadi MR, Abbaszadeh V, Gharesouran J, Dehghani H, Sabaie H, Hussen BM, Taheri M, Dilmaghnai NA, Rezazadeh M. Analysis of NFKB1 and NFKB2 gene expression in the blood of patients with sudden sensorineural hearing loss. International Journal of Pediatric Otorhinolaryngology. 2023;166:111470. https://doi.org/10.1016/j.ijporl.2023.111470
  • 8. Asadi MR, Abed S, Kouchakali G, Fattahi F, Sabaie H, Moslehian MS, Sharifi-Bonab M, Hussen BM, Taheri M, Ghafouri-Fard S, Rezazadeh M. Competing endogenous RNA (ceRNA) networks in Parkinson's disease: A systematic review. Frontiers in Cellular Neuroscience. 2023;17. https://doi.org/10.3389/fncel.2023.1044634
  • 9. Sabaie H, Talebi M, Gharesouarn J, Asadi MR, Jalaiei A, Arsang-Jang S, Hussen BM, Taheri M, Khoshnoud RJ, Rezazadeh M. Identification and Analysis of BCAS4/hsa-miR-185-5p/SHISA7 Competing Endogenous RNA Axis in Late-Onset Alzheimer's Disease Using Bioinformatic and Experimental Approaches. Frontiers in Aging Neuroscience. 2022;14. https://doi.org/10.3389/fnagi.2022.812169
  • 10. Sabaie H, Rouz SK, Kouchakali G, Heydarzadeh S, Asadi MR, Sharifi-Bonab M, Hussen BM, Taheri M, Ayatollahi SA, Rezazadeh M. Identification of potential regulatory long non-coding RNA-associated competing endogenous RNA axes in periplaque regions in multiple sclerosis. Frontiers in Genetics. 2022;13. https://doi.org/10.3389/fgene.2022.1011350
  • 11. Sabaie H, Gholipour M, Asadi MR, Abed S, Sharifi-Bonab M, Taheri M, Hussen BM, Brand S, Neishabouri SM, Rezazadeh M. Identification of key long non-coding RNA-associated competing endogenous RNA axes in Brodmann Area 10 brain region of schizophrenia patients. Frontiers in Psychiatry. 2022;13. https://doi.org/10.3389/fpsyt.2022.1010977
  • 12. Sabaie H, Gharesouran J, Asadi MR, Farhang S, Ahangar NK, Brand S, Arsang-Jang S, Dastar S, Taheri M, Rezazadeh M. Downregulation of miR-185 is a common pathogenic event in 22q11.2 deletion syndrome-related and idiopathic schizophrenia. Metabolic Brain Disease. 2022;37(4):1175-84. https://doi.org/10.1007/s11011-022-00918-5
  • 13. Mohammadisoleimani E, Firoozi Z, Naghizadeh MM, Asad AG, Jafari A, Pourjafarian MH, Ariafar A, Mansoori H, Dastsooz H, Sabaie H, Zeighami S, Mansoori Y. Expression analysis of hsa_circ_0020397, hsa_circ_0005986, hsa_circ_0003028, and hsa_circ_0006990 in renal cell carcinoma. Experimental and Molecular Pathology. 2022;129:104848. https://doi.org/10.1016/j.yexmp.2022.104848
  • 14. Hakimi P, Lotfalizad N, Pabarja L, Asadi MR, Gharesouran J, Dehghani H, Sabaie H, Danaie S, Hussen BM, Taheri M, Rezazadeh M. Association of seven fundamental genetic polymorphisms in long noncoding RNA MALAT1, SOX2OT and H19 with recurrent miscarriage in Turkish-Azeri Iranian population. Human Gene. 2022;33:201063. https://doi.org/10.1016/j.humgen.2022.201063
  • 15. Asadi MR, Talebi M, Gharesouran J, Sabaie H, Jalaiei A, Arsang-Jang S, Taheri M, Sayad A, Rezazadeh M. Analysis of ROQUIN, Tristetraprolin (TTP), and BDNF/miR-16/TTP regulatory axis in late onset Alzheimer's disease. Frontiers in Aging Neuroscience. 2022;14. https://doi.org/10.3389/fnagi.2022.933019
  • 16. Asadi MR, Moslehian MS, Sabaie H, Sharifi-Bonab M, Hakimi P, Hussen BM, Taheri M, Rakhshan A, Rezazadeh M. CircRNA-Associated CeRNAs Regulatory Axes in Retinoblastoma: A Systematic Scoping Review. Frontiers in Oncology. 2022;12. https://doi.org/10.3389/fonc.2022.910470
  • 17. Asadi MR, Gharesouran J, Sabaie H, Moslehian MS, Dehghani H, Arsang-Jang S, Taheri M, Mortazavi D, Hussen BM, Sayad A, Rezazadeh M. Assessing the expression of two post-transcriptional BDNF regulators, TTP and miR-16 in the peripheral blood of patients with Schizophrenia. BMC Psychiatry. 2022;22(1). https://doi.org/10.1186/s12888-022-04442-9
  • 18. Shiva S, Gharesouran J, Sabaie H, Asadi MR, Arsang-Jang S, Taheri M, Rezazadeh M. Expression Analysis of Ermin and Listerin E3 Ubiquitin Protein Ligase 1 Genes in Autistic Patients. Frontiers in Molecular Neuroscience. 2021;14. https://doi.org/10.3389/fnmol.2021.701977
  • 19. Sabaie H, Salkhordeh Z, Asadi MR, Ghafouri-Fard S, Amirinejad N, Behzadi MA, Hussen BM, Taheri M, Rezazadeh M. Long Non-Coding RNA- Associated Competing Endogenous RNA Axes in T-Cells in Multiple Sclerosis. Frontiers in Immunology. 2021;12. https://doi.org/10.3389/fimmu.2021.770679
  • 20. Sabaie H, Moghaddam MM, Moghaddam MM, Amirinejad N, Asadi MR, Daneshmandpour Y, Hussen BM, Taheri M, Rezazadeh M. Long non-coding RNA-associated competing endogenous RNA axes in the olfactory epithelium in schizophrenia: a bioinformatics analysis. Scientific Reports. 2021;11(1). https://doi.org/10.1038/s41598-021-04326-0
  • 21. Sabaie H, Moghaddam MM, Moghaddam MM, Ahangar NK, Asadi MR, Hussen BM, Taheri M, Rezazadeh M. Bioinformatics analysis of long non-coding RNA-associated competing endogenous RNA network in schizophrenia. Scientific Reports. 2021;11(1). https://doi.org/10.1038/s41598-021-03993-3
  • 22. Sabaie H, Dehghani H, Shiva S, Asadi MR, Rezaei O, Taheri M, Rezazadeh M. Mechanistic Insight Into the Regulation of Immune-Related Genes Expression in Autism Spectrum Disorder. Frontiers in Molecular Biosciences. 2021;8. https://doi.org/10.3389/fmolb.2021.754296
  • 23. Sabaie H, Amirinejad N, Asadi MR, Jalaiei A, Daneshmandpour Y, Rezaei O, Taheri M, Rezazadeh M. Molecular Insight Into the Therapeutic Potential of Long Non-coding RNA-Associated Competing Endogenous RNA Axes in Alzheimer's Disease: A Systematic Scoping Review. Frontiers in Aging Neuroscience. 2021;13. https://doi.org/10.3389/fnagi.2021.742242
  • 24. Jalaiei A, Asadi MR, Sabaie H, Dehghani H, Gharesouran J, Hussen BM, Taheri M, Ghafouri-Fard S, Rezazadeh M. Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review. Frontiers in Immunology. 2021;12. https://doi.org/10.3389/fimmu.2021.774002
  • 25. Farhang S, Sabaie H, Gharesouran J, Asadi MR, Arsang-Jang S, Ghafouri-Fard S, Taheri M, Rezazadeh M. Expression Analysis of Ermin and Listerin E3 Ubiquitin Protein Ligase 1 Genes in the Periphery of Patients with Schizophrenia. Journal of Molecular Neuroscience. 2021. https://doi.org/10.1007/s12031-021-01928-1
  • 26. Asadi MR, Rahmanpour D, Moslehian MS, Sabaie H, Hassani M, Ghafouri-Fard S, Taheri M, Rezazadeh M. Stress Granules Involved in Formation, Progression and Metastasis of Cancer: A Scoping Review. Frontiers in Cell and Developmental Biology. 2021;9. https://doi.org/10.3389/fcell.2021.745394
  • 27. Asadi MR, Moslehian MS, Sabaie H, Poornabi M, Ghasemi E, Hassani M, Hussen BM, Taheri M, Rezazadeh M. Stress Granules in the Anti-Cancer Medications Mechanism of Action: A Systematic Scoping Review. Frontiers in Oncology. 2021;11. https://doi.org/10.3389/fonc.2021.797549
  • 28. Asadi MR, Moslehian MS, Sabaie H, Jalaiei A, Ghafouri-Fard S, Taheri M, Rezazadeh M. Stress Granules and Neurodegenerative Disorders: A Scoping Review. Frontiers in Aging Neuroscience. 2021;13. https://doi.org/10.3389/fnagi.2021.650740
  • 29. Asadi MR, Hassani M, Kiani S, Sabaie H, Moslehian MS, Kazemi M, Ghafouri-Fard S, Taheri M, Rezazadeh M. The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review. Frontiers in Aging Neuroscience. 2021;13. https://doi.org/10.3389/fnagi.2021.709568
  • 30. Ahangar NK, Hemmat N, Khalaj-Kondori M, Shadbad MA, Sabaie H, Mokhtarzadeh A, Alizadeh N, Derakhshani A, Baghbanzadeh A, Dolatkhah K, Silvestris N, Baradaran B. The Regulatory Cross-Talk between microRNAs and Novel Members of the B7 Family in Human Diseases: A Scoping Review. International Journal of Molecular Sciences. 2021;22(5):2652. https://doi.org/10.3390/ijms22052652
  • 31. Sabaie H, Ahangar NK, Ghafouri-Fard S, Taheri M, Rezazadeh M. Clinical and genetic features of PEHO and PEHO-Like syndromes: A scoping review. Biomedicine & Pharmacotherapy. 2020;131:110793. http://dx.doi.org/10.1016/j.biopha.2020.110793

Research Experience

  • 2025 - Present
    Research Assistant
    Cellular and Molecular Endocrine Research Center | Tehran, Iran
    • Principal Investigator: Dr. Mahdi Akbarzadeh
    • Primary duties:
    • Perform integrative single-nucleus multiomics analyses to investigate cell-type-specific regulatory mechanisms underlying complex human diseases.
    • Apply high-dimensional weighted gene co-expression network analysis (hdWGCNA) to single-cell transcriptomic data to identify disease-relevant gene modules and hub genes.
    • Conduct Mendelian randomization, colocalization, and fine-mapping analyses to infer causal relationships between genetically regulated gene expression and disease susceptibility.
    • Co-authored a review of computational methods for CNV detection and disease association, with emphasis on methodological advances and genomic medicine.
    • Co-authored a comprehensive review of diagnostic transcriptomics in rare genetic disease, focusing on RNA-seq-based variant interpretation, aberrant splicing, computational outlier detection, and clinical implementation.
  • 2024 - Present
    Research Assistant
    Tabriz University of Medical Sciences | Tabriz, Iran
    • Principal Investigator: Dr. Maryam Rezazadeh
    • Primary duties:
    • Use systems biology, RNA-seq transcriptomic analysis, and weighted gene co-expression network analysis (WGCNA) to identify gene modules, hub genes, and regulatory networks associated with neurological conditions.
    • Detect and interpret variants from exome sequencing data.
    • Assist the principal investigator with manuscript and grant proposal preparation.
    • Mentor medical, master’s, and Ph.D. students in research activities.
  • 2022 - 2023
    Researcher
    Directorate of Health, Rescue and Treatment | Tehran, Iran
    • Project:
    • Conducted a research project under the Iranian National Elite Foundation program in lieu of mandatory military service.
    • Integrated bioinformatic and experimental approaches to identify peripheral blood-based biomarkers for major depressive disorder.
  • 2019 - 2021
    Student Research Assistant
    Tabriz University of Medical Sciences | Tabriz, Iran
    • Principal Investigator: Dr. Maryam Rezazadeh
    • Main Projects:
    • Identified and examined ceRNA regulatory axes in neurogenetic disorders by reanalyzing publicly available microarray datasets and applying complementary molecular methods.
    • Assessed the expression of key genes in neurogenetic conditions using PCR, RT-PCR, and agarose gel electrophoresis.
    • Conducted systematic and scoping reviews of genetic aspects of human diseases, with an emphasis on neurogenetic conditions.

Teaching Experience

  • 2021
    Teaching Assistant
    Tabriz University of Medical Sciences | Tabriz, Iran
    • Delivered weekly lectures on microarray data analysis.

Skills

  • Programming and Computational Skills
    • R: Proficient with statistical modeling, data analysis, visualization, and reproducible research.
    • Python: Experienced with data analysis and scientific computing for genomic applications.
    • Linux/Unix and Bash: Skilled with command-line workflows and pipeline automation.
    • Git/GitHub: Experienced with version control and collaborative development.
    • Markdown/R Markdown: Proficient with reproducible documentation and reporting.
  • Statistical and Computational Genomics
    • Skilled with two-sample and summary-data-based Mendelian randomization, colocalization and statistical fine-mapping (TwoSampleMR, SMR/HEIDI, MR-PRESSO, GCTA-COJO, coloc, and SuSiE).
    • Experienced with Comprehensive Meta-Analysis (CMA).
  • Functional Genomics
    • Single-Cell Multiomics: Experienced with preprocessing, normalization, multimodal integration, clustering, trajectory inference, network analysis, motif activity, and cell–cell communication analysis (Drop-seq pipeline, Seurat, decontX, scDblFinder, Signac, Monocle, hdWGCNA, chromVAR, and CellChat).
    • Bulk RNA-seq: Experienced with end-to-end workflows including QC, alignment, quantification, and differential expression (FastQC, Trimmomatic, HISAT2, STAR, featureCounts, HTSeq, StringTie, Kallisto, Salmon, edgeR, DESeq2, Ballgown, Sleuth, Picard, and GATK).
    • Co-expression and network analysis: Skilled with co-expression, interaction, and ceRNA regulatory network analysis.
    • Microarray Analysis: Proficient with preprocessing, normalization, and differential expression analysis.
    • Genomic Variant Analysis: Skilled with variant calling, annotation, and interpretation.
  • Experimental and Molecular Biology Skills
    • Molecular Genetics Techniques: Skilled with DNA extraction, RNA isolation, NanoDrop spectrophotometry, agarose gel electrophoresis, cDNA synthesis, PCR, RT-qPCR, and cell culture.
    • Primer Design and Reference Gene Validation: Proficient with Primer3, Primer-BLAST, Oligo7, Gene Runner, NormFinder, and geNorm.
    • RT-qPCR Data Analysis: Proficient with relative expression analysis and visualization (R, GraphPad Prism, SPSS, and GenEx).
  • Other
    • Systematic Literature Search and Evidence Synthesis: Proficient with PubMed, Embase, Scopus, Web of Science, Cochrane, ProQuest, and Google Scholar.
    • Reference Management: Proficient with Zotero, EndNote, and ResearchRabbit.
    • Scientific Visualization: Proficient with BioRender, Mind the Graph, and PowerPoint.

Conference Presentations

  • Poster Presentation
    • Sabaie H, Asadi MR, Salkhordeh Z, Rezazadeh M. Investigation of competing endogenous RNA regulation of BCAS4 and SHISA7 in tau pathology in Alzheimer's disease. The first international conference and the tenth national bioinformatics conference of Iran, 22-24 February 2022 in Kish Island, Iran.

Workshops and Training

  • 2026
    Comprehensive Training Program in Statistical Data Analysis, R, Python, and Machine Learning
    Shahid Beheshti University of Medical Sciences | Tehran, Iran (online)
  • 2025
    Summary-data-based Mendelian Randomization
    Shahid Beheshti University of Medical Sciences | Tehran, Iran (online)
  • 2024
    Mendelian Randomization
    Shahid Beheshti University of Medical Sciences | Tehran, Iran (online)
  • 2024
    R Advanced Workshop for Data Science
    Shahid Beheshti University of Medical Sciences | Tehran, Iran (online)
  • 2024
    R Preliminary Workshop for Data Science
    Shahid Beheshti University of Medical Sciences | Tehran, Iran (online)
  • 2024
    Linux Essentials
    Shahid Beheshti University of Medical Sciences | Tehran, Iran (online)
  • 2023
    Academic Writing
    Hanifa Academy | Tehran, Iran (online)
  • 2020
    Academic Writing
    Tabriz University of Medical Sciences | Tabriz, Iran
  • 2020
    R Programming
    Tabriz University of Medical Sciences | Tabriz, Iran
  • 2020
    Basic Bioinformatics
    Tabriz University of Medical Sciences | Tabriz, Iran
  • 2020
    Biostatistics
    Tabriz University of Medical Sciences | Tabriz, Iran
  • 2020
    Ethics in Research and Publication
    Tabriz University of Medical Sciences | Tabriz, Iran
  • 2019
    Principles of systematic review studies and search strategy
    Tabriz University of Medical Sciences | Tabriz, Iran
  • 2019
    Research Methodology
    Tabriz University of Medical Sciences | Tabriz, Iran
  • 2019
    Proposal Writing
    Tabriz University of Medical Sciences | Tabriz, Iran

Honors and Awards

  • 2023
    • Selected Researcher | Research Week, Clinical Research Development Unit, Tabriz Valiasr Hospital

Science Community Service

  • Reviewed manuscripts for international journals, including: Scientific Reports; Heliyon; PLOS ONE; Medicine; Aging; Annals of Human Biology; BMC Neurology; BMC Medical Genomics; Molecular Neurobiology; Molecular Medicine; Molecular Therapy – Nucleic Acids; Biomedicine & Pharmacotherapy; International Immunopharmacology; Functional & Integrative Genomics; Gene; Cell Cycle; Multiple Sclerosis and Related Disorders; Journal of Diabetes Investigation; Oncology Letters; Discover Oncology; Current Eye Research; Bioengineered; Iranian Journal of Allergy, Asthma and Immunology; Minerva Cardiology and Angiology.

Volunteer Academic Service

  • 2022 - Now
    • Mentored medical and graduate students in research design, practical implementation, and data analysis.
  • 2018 - 2021
    • Advised candidates preparing for the Iranian national entrance examination for M.Sc. programs in Human Genetics.

Interests and Activities

  • Running
  • Travel
  • Reading in Philosophy and History

References

  • Maryam Rezazadeh, Ph.D. (M.Sc. Supervisor)
  • Mahdi Akbarzadeh, Ph.D. (Principal Investigator)
    • Assistant Professor
    • Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    • akbarzadehms@sbmu.ac.ir
    • Google Scholar
  • Amir Hossein Saeidian, Ph.D. (Research Mentor)
  • Hakon Hakonarson, M.D., Ph.D. (Research Mentor)
  • Hassan Vahidnezhad, Ph.D. (Research Collaborator)
  • Leila Youssefian, Ph.D. (Research Collaborator)